“Indy” Poised for second biggest Memorial Day.

“Indiana Jones and the Kingdom of the Crystal Skull” is poised to become the 2nd largest opening for a Memorial Day weekend, with an estimated four-day gross of $126 million from 4,260 screens acording to Variety.

Including Thursday’s haul, “Crystal Skull’s” five-day opening gross looks to nab a hefty $151 million, according to Paramount, which is distributing the film for George Lucas‘ LucasFilms.

“Crystal Skull’s” strong box office debut marks a triumphant return for the action-adventure franchise.

Tentpole stars Harrison Ford, Cate Blanchett, Shia LaBeouf, Karen Allen and Ray Winstone.

Disney’s “Pirates of the Caribbean: At World’s End” opened last year at the same time and continues to hold the record for best Memorial Day opener, grossing $139.8 million for the four-day holiday.

“Crystal Skull” was able to edge out 20th Century Fox‘s “X Men: The Last Stand,” which posted a four-day Memorial Day gross of $122.8 million in 2006.

Elsewhere at the Memorial Day box office, Disney holdover “Chronicles of Narnia: Prince Caspian” placed No. 2, declining an estimated 58.2% in its second frame for a Friday-to-Sunday cume of $23 million from 3,929 runs for a cume of $91 million in the sequel’s first 10 days. Disney won’t release Monday box office estimates until Monday.

Par’s “Iron Man’ continued to impress in its fourth frame, declining just 37% for a Friday-to-Sunday total of $20.1 million for a new cume of $257.8 million.

As with “Prince Caspian,” Par only provided weekend box office estimates for “Iron Man.

Twentieth Century Fox‘s “What Happens in Vegas” came in No. 4 at the Memorial Day box office, declining only 35% in its third frame to an estimated $9 million from 3,1888 runs for a cume of $54.2 million.

Fox will provide Monday box office results on Monday.

Warner Bros.’ “Speed Racer” placed No. 5 for the weekend, declining an estimated 51% in its third frame to $4 million for a new cume of $36.2 million through Sunday.

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