Horton Hears a Who took home the biggest weekend haul for 2008 so far with a hefty 45.1 million dollars, studios are estimating. USA Today reports,

The haul was about $5 million more than projected and broke Disney’s stranglehold on the top five openings for animated movies. 20th Century Fox’s Horton took fifth place, behind Finding Nemo, Monsters, Inc., Cars and Ratatouille.

And the film, featuring the voices of Jim Carrey and Steve Carell, did it largely with teens and adults without children. About 47% of the audience was non-family, according to Fox’s exit surveys.

Horton looks like it will easily surpass the 100 million mark with only April 4th’s release of Nim’s Island offered as alternative family audience fare. With the success of Horton, it looks like more Seuss films are on the horizon. Blue Sky Studios is already in the process of developing Green Eggs and Ham as a feature film with a tentative release date for 2011.